Raziye Mohammadpour, Mostafa Yazdimamaghani, Darwin L. Cheney, Jolanta Jedrzkiewicz and Hamidreza Ghandehari were honored to have their article entitled “Subchronic Toxicity of Silica Nanoparticles as a Function of Size and Porosity” featured on the cover of Journal of Controlled Release July issue (volume 304).

Despite the promise of inorganic nanomaterials for use in delivery, diagnosis, and therapy there is a gap in understanding the potential long-term toxicity of these particles. This study explored the acute and subchronic toxicity of silica nanoparticles as a function of size and porosity in male and female mice. Results demonstrate that acute studies, while useful, do not provide a detailed projection of potential long term effects and that the sex of the species can play a role in the biological fate of inorganic nanoparticles. For details of this study click here.

For a recent review article on the need for chronic toxicity evaluation of inorganic nanoparticles click here.