“Targeted Temperature Management as a Strategy for Hearing Preservation”
Dr. Suhrud Rajguru, PhD
Professor of Biomedical Engineering and Otolaryngology,
Co-Director of Institute of Neural Engineering,
Co-Director UM Clinical and Translational Science Institute,
University of Miami
Monday, May 16th at 9:00 am
On Zoom
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Mild therapeutic hypothermia is known to provide neuroprotection following ischemic and traumatic injuries. We have extended the application of localized hypothermia using patented devices and systems using unique protocols to the protection of inner ear-related functions. We have shown significant neuroprotection during cochlear implant electrode insertion, noise- and blast-induced injuries to the inner ear, and very recently, we have extended its application to tinnitus. Our results suggest significant protection of hair cells, synaptic elements, and peripheral ganglion from damage caused by the oxidative and inflammatory trauma and subsequent long-term protection of function. Our laboratory studies the molecular pathways and gene networks significant for otoprotection to further exploit benefits of hypothermia and improve its translation to clinical practice. We are leading the development of a clinical device and novel applications in preservation of auditory and vestibular function during neurotologic surgeries.
Suhrud Rajguru, Ph.D., is a Professor of Biomedical Engineering and Otolaryngology at the University of Miami and a co-founder and Chief Scientific Officer of Restor-Ear Devices, LLC. He completed his undergraduate studies in Mumbai, India prior to pursuing doctoral studies at the University of Utah. Dr. Rajguru’s research foci are on the investigations of pathophysiology, the diagnosis and treatment of various hearing and balance disorders. An educator, scientist and entrepreneur, he is an author of numerous peer-reviewed publications and is a named inventor on issued and pending patent applications. His research is supported by the National Institutes of Health and industry partners and he is actively involved in the education and mentoring of undergraduate and graduate students. He leads the University of Miami’s I-Corps@NCATS program supported by NCATS. He is co-director of the Institute for Neural Engineering at the University of Miami and an Co-Director of the Workforce Development and Team Science programs at the Clinical and Translational Science Institute. Recently he was awarded the Merit Grant by Veterans Administration and he’s been appointed as a Health Research Scientist at Miami VA.
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