Profile

The key focus of my lab is engineering cell function utilizing multiplex CRISPRa/CRISPRi systems and genome-wide screens to develop novel therapeutics for a broad range of disorders, including the musculoskeletal system, nervous system, and fibrosing disorders. Our lab was the first to investigate CRISPRi regulation in MSC/ASC populations and has since pioneered multiplex regulation and genome-wide screens for tissue engineering and gene therapy applications. Our most recent discovery is a previously uncharacterized transcriptional regulator of senescence/DNA damage, ZNF865, which has therapeutic applications to musculoskeletal disease, cancer, neurodegenerative disorders, and aging.